Which condition is characterized by a sudden onset of bleeding on probing (BOP) and general fatigue?

The condition characterized by a sudden onset of bleeding on probing (BOP) and general fatigue is leukemia. In leukemia, the proliferation of abnormal white blood cells can lead to complications affecting the bone marrow's ability to produce healthy blood cells, resulting in various systemic symptoms such as fatigue and weakness.

Oral manifestations, including bleeding gums, are common because the healthy balance of blood components is disrupted. Patients may present with a significant increase in bleeding tendencies, as the platelet function may be impaired, and the overall condition can lead to an increase in mucosal friability.

This association of bleeding on probing with systemic symptoms like fatigue is a pivotal aspect of diagnosing leukemia, setting it apart from other conditions such as acute or chronic gingivitis, which typically do not present with systemic symptoms to the same degree or sudden onset of bleeding as a primary feature. Drug-induced overgrowth may cause gingival enlargement but is not directly linked to such acute systemic symptoms or fatigue.