Which of the following is NOT a potential etiology of gingival enlargement?

Mechanical trauma is not typically recognized as a potential etiology of gingival enlargement. Gingival enlargement often involves the overgrowth of gum tissue, which can be driven by a variety of factors, including inflammatory responses, systemic conditions, and certain medications.

Plasma cell gingivitis, categorized as an allergic response, can lead to tissue enlargement due to inflammation. Acute gingival inflammation may result from factors like plaque accumulation, which also contributes to gingival swelling as the body's immune response attempts to address the irritation and infection. Drug-induced reactions, such as those caused by antihypertensive medications or anticonvulsants, can directly lead to gingival overgrowth as a side effect.

In contrast, while mechanical trauma can cause localized changes, such as recession or inflammation, it does not inherently promote the generalized or exaggerated growth of gum tissue associated with gingival enlargement. Therefore, understanding the specific mechanisms of gingival enlargement and the conditions that foster it is crucial for effective periodontal diagnosis and treatment.